Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19).
Identifieur interne : 000219 ( 2020/Analysis ); précédent : 000218; suivant : 000220Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19).
Auteurs : Samuel James Brake [Australie] ; Kathryn Barnsley [Australie] ; Wenying Lu [Australie] ; Kielan Darcy Mcalinden [Australie] ; Mathew Suji Eapen [Australie] ; Sukhwinder Singh Sohal [Australie]Source :
- Journal of clinical medicine [ 2077-0383 ] ; 2020.
Abstract
The epicenter of the original outbreak in China has high male smoking rates of around 50%, and early reported death rates have an emphasis on older males, therefore the likelihood of smokers being overrepresented in fatalities is high. In Iran, China, Italy, and South Korea, female smoking rates are much lower than males. Fewer females have contracted the virus. If this analysis is correct, then Indonesia would be expected to begin experiencing high rates of Covid-19 because its male smoking rate is over 60% (Tobacco Atlas). Smokers are vulnerable to respiratory viruses. Smoking can upregulate angiotensin-converting enzyme-2 (ACE2) receptor, the known receptor for both the severe acute respiratory syndrome (SARS)-coronavirus (SARS-CoV) and the human respiratory coronavirus NL638. This could also be true for new electronic smoking devices such as electronic cigarettes and "heat-not-burn" IQOS devices. ACE2 could be a novel adhesion molecule for SARS-CoV-2 causing Covid-19 and a potential therapeutic target for the prevention of fatal microbial infections, and therefore it should be fast tracked and prioritized for research and investigation. Data on smoking status should be collected on all identified cases of Covid-19.
DOI: 10.3390/jcm9030841
PubMed: 32244852
Affiliations:
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Medicine, School of Health Sciences, University of Tasmania, Launceston, Tasmania 7248, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, University of Tasmania, Launceston, Tasmania 7248</wicri:regionArea><wicri:noRegion>Tasmania 7248</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of clinical medicine</title><idno type="ISSN">2077-0383</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The epicenter of the original outbreak in China has high male smoking rates of around 50%, and early reported death rates have an emphasis on older males, therefore the likelihood of smokers being overrepresented in fatalities is high. In Iran, China, Italy, and South Korea, female smoking rates are much lower than males. Fewer females have contracted the virus. If this analysis is correct, then Indonesia would be expected to begin experiencing high rates of Covid-19 because its male smoking rate is over 60% (Tobacco Atlas). Smokers are vulnerable to respiratory viruses. Smoking can upregulate angiotensin-converting enzyme-2 (ACE2) receptor, the known receptor for both the severe acute respiratory syndrome (SARS)-coronavirus (SARS-CoV) and the human respiratory coronavirus NL638. This could also be true for new electronic smoking devices such as electronic cigarettes and "heat-not-burn" IQOS devices. ACE2 could be a novel adhesion molecule for SARS-CoV-2 causing Covid-19 and a potential therapeutic target for the prevention of fatal microbial infections, and therefore it should be fast tracked and prioritized for research and investigation. Data on smoking status should be collected on all identified cases of Covid-19.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Brake, Samuel James" sort="Brake, Samuel James" uniqKey="Brake S" first="Samuel James" last="Brake">Samuel James Brake</name></noRegion><name sortKey="Barnsley, Kathryn" sort="Barnsley, Kathryn" uniqKey="Barnsley K" first="Kathryn" last="Barnsley">Kathryn Barnsley</name><name sortKey="Eapen, Mathew Suji" sort="Eapen, Mathew Suji" uniqKey="Eapen M" first="Mathew Suji" last="Eapen">Mathew Suji Eapen</name><name sortKey="Lu, Wenying" sort="Lu, Wenying" uniqKey="Lu W" first="Wenying" last="Lu">Wenying Lu</name><name sortKey="Mcalinden, Kielan Darcy" sort="Mcalinden, Kielan Darcy" uniqKey="Mcalinden K" first="Kielan Darcy" last="Mcalinden">Kielan Darcy Mcalinden</name><name sortKey="Sohal, Sukhwinder Singh" sort="Sohal, Sukhwinder Singh" uniqKey="Sohal S" first="Sukhwinder Singh" last="Sohal">Sukhwinder Singh Sohal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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